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Research is 'urgently needed' on heart muscle disease in children, according to UB chair of AHA writing group

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Wed, May 29th 2019 04:30 pm

Though rare, these conditions cause some of worst outcomes in pediatric cardiology, according to AHA scientific statement published in Circulation

By the University at Buffalo

Cardiomyopathy is a heart condition involving abnormalities of the muscle fibers, which contract with each heartbeat. Nearly half of children with this type of heart disease either undergo a heart transplant or die within two years of being diagnosed.

That somber statistic is part of an American Heart Association (AHA) scientific statement published on May 28 in Circulation. The statement was produced by a writing group led by Steven E. Lipshultz, M.D., the A. Conger Goodyear Professor and chair of the department of pediatrics in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. Lipshultz is also pediatric chief-of-service at Kaleida Health, medical director of pediatric services business development at the John R. Oishei Children’s Hospital, and president of UBMD Pediatrics.

The AHA asked Lipshultz to chair the group in 2016 to assess the current state of the field of cardiomyopathy in children, in terms of classification and diagnosis.

Pediatric cardiomyopathy occurs in approximately 1 in 100,000 U.S. children. In many cases, it means the heart isn’t pumping blood efficiently. Symptoms can include shortness of breath, arrhythmias, dizziness, swollen hands and feet, and other indications.

The authors point out that, while children are afflicted with the condition at roughly the same incidence as some childhood cancers – including lymphoma, Wilms tumor and neuroblastoma – the quantity of “published research and scientific conferences focused on pediatric cardiomyopathy are sparser than for those cancers.”

The purpose of the scientific statement is to help determine future research priorities in order to “achieve earlier diagnosis, improved clinical outcomes, and better quality of life for these children and their families.”

Among Worst Outcomes in Pediatric Cardiology

While heart muscle disease in children is rare, the authors note it can result in “some of the worst pediatric cardiology outcomes.”

For example, until recently, the percentage of children with cardiomyopathy who underwent a heart transplant had not declined and the condition remains the leading cause of transplantation for children older than 1 year.

“These findings are concerning, because they often result in unimaginable suffering for these children and their families,” Lipshultz said. “For this reason, research in pediatric cardiomyopathy is urgently needed.”

For example, he mentioned a multi-center study that he led involving 98 centers across the U.S. and Canada and conducted by the National Institutes of Health-supported Pediatric Cardiomyopathy Registry. “This study showed that for children with heart failure from dilated cardiomyopathy – where the heart’s main pumping chamber is enlarged and weakened – there has been a dramatic improvement in outcomes of medical management in the past few years and significantly fewer of these patients die from heart disease.”

Results from this international study also showed, for the first time, improved transplant-free survival rates for pediatric dilated cardiomyopathy patients.

“But there is still so much more to do,” Lipshultz said.

Although heart transplantation has improved outcomes for children with dilated cardiomyopathy, it is limited by donor heart availability. Lipshultz said new therapies, including new medications, advanced intensive care and artificial heart machines, and comprehensive chronic illness management are now being used to treat children with dilated cardiomyopathy.

Unknown Causes

The authors note that, according to studies from the Pediatric Cardiomyopathy Registry, the cause of the disease remains unknown in the vast majority of cases, another reason why more research is needed.

While classification and causes of cardiomyopathies in infancy, childhood and adolescence can have similarities with those seen in adults, the statement cautions that many pediatric cases have unique pathogeneses and risk factors, and the disease progresses differently from cases in adults.

Because of the lack of data on pediatric cardiomyopathies, the group concluded that it couldn’t provide evidence-based guidelines. “Rather we have given a current perspective of the state of this field to illustrate what is known and where knowledge gaps exist for future discovery.”

Many of the findings reported in the AHA scientific statement were conducted through the Pediatric Cardiomyopathy Registry, founded by Lipshultz and his colleagues in 1990 to study the outcomes of children with various heart muscle disorders. The registry is sponsored by the NIH and the Children's Cardiomyopathy Foundation, which was founded in 2001 with Lipshultz’s help by Lisa Yue, now its president and the mother of two sons who died from cardiomyopathy. Lipshultz chairs its medical advisory board, which partners with the AHA on funding research grants.

Lipshultz said recent findings from the registry demonstrate the value of leading pediatric heart centers throughout North America gathering information and sharing best practices to improve outcomes.

"We have been able to reduce failure of medical management by about 50%, which translates to a large number of children with dilated cardiomyopathy who are alive without heart transplant, compared to children with dilated cardiomyopathy at the same centers in the past who would not have survived or would have needed a heart transplant. When you consider that in this population, fully half the children who are living today would not have survived in the past, this is truly incredible," he said.

That research was published in the Journal of the American College of Cardiology in 2017.

Lipshultz is the principal investigator of a number of NIH grants that are actively studying pediatric cardiomyopathy to promote discovery and reach better outcomes, with many of these studies now being coordinated in Buffalo. One is evaluating the heart status of children who have been exposed to, and treated for, viral infections, with the goal of understanding the causes of the cardiomyopathies that they later developed. Another is a 30-year longitudinal study focused on the long-term outcomes of patients who took a medication designed to provide short-term protection against heart damage.

Writing group co-authors are Yuk M. Law, M.D. (vice-chair); Alfred Asante-Korang, M.D.; Eric D. Austin, M.D., M.S.C.I.; Anne I. Dipchand, M.D.; Melanie D. Everitt, M.D.; Daphne T. Hsu, M.D.; Kimberly Y. Lin, M.D.; Jack F. Price, M.D.; James D. Wilkinson, M.D., M.P.H.; and Steven D. Colan, M.D.

The Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, part of the State University of New York, is among the nation’s oldest medical schools. Its faculty and medical residents provide care for the community’s diverse populations through strong clinical partnerships and the UBMD Physicians’ Group practice plan. The school’s new seven-story building downtown anchors Buffalo’s comprehensive academic health center, putting superior medical education, clinical care and pioneering research in close proximity. The Jacobs School advances health and wellness across the life span by educating tomorrow’s leaders in health care and biomedical sciences, conducting innovative research and providing outstanding clinical care.

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