Samir Haj-Dahmane, Ph.D., senior research scientist at the University at Buffalo Research Institute on Addictions, has discovered how certain neurotransmitters are transported and reach their targets in the brain, which could lead to new drug therapies to help anxiety and other negative brain functions.
In a study published by the Proceedings of the National Academy of Sciences, researchers from RIA and Stony Brook University show that a particular protein, known as fatty-acid-binding protein 5 (FABP5), is key to how endocannabinoids travel from neurons to receptors in the brain. This research, led by Haj-Dahmane, was supported by the National Institutes of Health and SUNY REACH (Research Excellence in Academic Health).
Endocannabinoids are naturally produced lipids in the brain that control numerous physiological and behaviors functions, including emotions, stress, pain, motor control and cognition. Released from brain cells, endocannabinoids must travel through a liquid environment to reach and activate cannabinoid receptors and produce their physiological effects.
"For nearly 40 years, a longstanding question in the field of endocannabinoid research is how these lipids can travel through an aqueous (water-like) environment and reach their specific targets," Haj-Dahmane said. "Our research identifies FABP5 as the critical element in achieving this process."
This new discovery is a breakthrough in the current understanding of endocannabinoid function in the brain, which is significant because of the multiple physiological and behaviors function of the endocannabinoid system, including stress, addiction, memory, appetite and pain regulation.
"Given the growing interest in the therapeutic potential of endocannabinoids, it is very likely that FABP5 will be the focus of future translational research to develop drug therapies for psychiatric and neurological disorders involving this system," Haj-Dahmane said.
The study was co-authored by Roh-Yu Shen, Ph.D., and Panayotis (Peter) K. Thanos, Ph.D., of the UB Research Institute on Addictions, and Matthew W. Elmes, Ph.D., Keith Studholme, Ph.D., Marta P. Kanjiya, Ph.D., Diane Bogdan, Ph.D., Jeremy T. Miyauchi, Ph.D., Stella E. Tsirka, Ph.D., Dale G. Deutsch, Ph.D., and Martin Kaczocha, Ph.D., of Stony Brook University.
RIA is a research center of the University at Buffalo and a national leader in the study of alcohol and substance abuse issues. RIA's research programs, most of which have multiple-year funding, are supported by federal, state and private foundation grants. Located on UB's Downtown Campus, RIA is a member of the Buffalo Niagara Medical Campus and a key contributor to UB's reputation for research excellence. To learn more, visit buffalo.edu/ria